Regulating Gene Expression through RNA Nuclear Retention
نویسندگان
چکیده
منابع مشابه
Regulating Gene Expression through RNA Nuclear Retention
Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified CTN-RNA, a mouse tissue-specific approximately 8 kb nuclear-retained poly(A)+ RNA that regulates the level of its protein-coding partner. CTN-RNA is transcribed from the protein-coding mouse cationic amino acid transporter 2 (mCAT2) gene through alternative promoter and poly(A) site usage. CTN-RNA is diffusel...
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Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain enriched in pre-mRNA processing factors. 7SK RNA, in association with HEXIM 1 and 2, is involved in the inhibition of transcriptional elongation by RNA polymerase II. Inhibition occurs via sequestr...
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Yoshinari Yasuda, Yoichi Miyamoto, Tomoko Yamashiro, Munehiro Asally, Ayumi Masui, Chin Wong, Kate L Loveland and Yoshihiro Yoneda* Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia, Department of Anatomy and ...
متن کاملNuclear retention of importin α coordinates cell fate through changes in gene expression.
Various cellular stresses including oxidative stress induce a collapse of the Ran gradient, which causes accumulation of importin α in the nucleus and a subsequent block of nuclear protein import. However, it is unknown whether accumulated importin α performs roles in the nucleus after its migration in response to stress. In this study, we found that nuclear-retained importin α2 binds with DNas...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.08.033